Avian influenza A viruses: from zoonosis to pandemic
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چکیده
منابع مشابه
Influenza: from zoonosis to pandemic
Global surveillance and advances in vaccine technology are essential to answer the threat of influenza pandemics http://ow.ly/Yt3e4.
متن کاملPandemic threat posed by avian influenza A viruses.
Influenza pandemics, defined as global outbreaks of the disease due to viruses with new antigenic subtypes, have exacted high death tolls from human populations. The last two pandemics were caused by hybrid viruses, or reassortants, that harbored a combination of avian and human viral genes. Avian influenza viruses are therefore key contributors to the emergence of human influenza pandemics. In...
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Cross-species transmission of a highly pathogenic subtype of influenza A virus directly from birds to humans has raised many concerns. The radical methods of immune evasion and the possibility of human-to-human transmission as a result of gene reassortment between the human and avian viral subtypes pose an imminent threat of a global pandemic. The growing reservoir of circulating influenza amon...
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While the basic principles of immunity to the influenza A viruses are probably similar for all vertebrates, detailed understanding is based largely on experiments in laboratory mice. Elements of the innate response limit early virus replication, although high pathogenicity strains can trigger effusive cytokine/chemokine production and lethal shock. Virus clearance is normally mediated via CD8+ ...
متن کاملCharacterization of Neuraminidases from the Highly Pathogenic Avian H5N1 and 2009 Pandemic H1N1 Influenza A Viruses
To study the precise role of the neuraminidase (NA), and its stalk region in particular, in the assembly, release, and entry of influenza virus, we deleted the 20-aa stalk segment from 2009 pandemic H1N1 NA (09N1) and inserted this segment, now designated 09s60, into the stalk region of a highly pathogenic avian influenza (HPAI) virus H5N1 NA (AH N1). The biological characterization of these wi...
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ژورنال
عنوان ژورنال: Future Virology
سال: 2014
ISSN: 1746-0794,1746-0808
DOI: 10.2217/fvl.14.30